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This book provides a comprehensive overview of acute and chronic critical limb ischemia cli loss of an extremity or a portion thereof is not necessarily a life ending process but it is a debilitating experience whether involvement is of the upper or lower extremity it reviews the. Chronic limb ischaemia is peripheral arterial disease that results in a symptomatic reduced blood supply to the limbs it is typically caused by atherosclerosis rarely vasculitis and will commonly affect the lower limbs however the upper limbs and gluteals can also be affected around 15 20 individuals over 70yrs have peripheral arterial disease. Chronic limb threatening ischemia clti also known as critical limb ischemia cli is an advanced stage of peripheral artery disease padit is defined as ischemic rest pain arterial insufficiency ulcers and gangrenethe latter two conditions are jointly referred to as tissue loss reflecting the development of surface damage to the limb tissue due to the most severe stage of ischemia. Chronic critical limb ischemia is manifested by pain at rest nonhealing wounds and gangrene ischemic rest pain is typically described as a burning pain in the arch or distal foot that occurs . Critical limb ischemia cli is a severe blockage in the arteries of the lower extremities which markedly reduces blood flow it is a serious form of peripheral arterial disease or pad but less common than claudicationpad is caused by atherosclerosis the hardening and narrowing of the arteries over time due to the buildup of fatty deposits called plaque